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Updated: Feb 4, 2026
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The Production of Pluripotent Stem Cells from Mouse Amniotic Fluid Cells Using a Transposon System
Published on: February 28, 2017
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Amniotic fluid as a source of engraftable stem cells
1Center of Excellence for Aging and Brain Repair, Tampa, FL 33612, USA.
Brain Circulation
|October 3, 2018
Summary
Amniotic fluid-derived stem cells (AFSC) show potential in regenerative medicine due to their differentiation capabilities and minimal senescence. These stem cells offer a promising source for treating various diseases and for therapeutic applications.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Developmental Biology
Background:
- Stem cells are crucial for regenerative medicine and treating human diseases.
- Amniotic fluid-derived stem cells (AFSC) exhibit characteristics of both adult and embryonic stem cells.
- AFSC possess multipotent differentiation potential and limited replicative senescence.
Purpose of the Study:
- To review the therapeutic potential of amniotic fluid-derived stem cells (AFSC).
- To highlight AFSC as a promising source for regenerative medicine applications.
- To discuss the convenience of AFSC harvesting for neonatal treatment and banking.
Main Methods:
- This paper is a review of existing literature.
- Data is supported by findings from the authors' research center and experiences.
- Relevant studies were identified through database searches, including PubMed.
Main Results:
- AFSC can differentiate into multiple cell types from all three germ layers.
- AFSC demonstrate robust proliferative capacity, exceeding 250 doublings with minimal senescence.
- Amniotic fluid represents a viable and convenient source for stem cell collection.
Conclusions:
- AFSC hold significant promise as a stem cell source for regenerative medicine.
- Further research into AFSC therapeutic applications is warranted.
- The ease of collection and banking makes AFSC attractive for clinical use.
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