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Knut Lien, Olav Spigset, Andreas Austgulen Westin

    Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
    |October 3, 2018
    PubMed
    Summary
    This summary is machine-generated.

    The 2012 digitoxin to digoxin switch impacted patient digitalis serum concentrations. While many saw reductions, some patients experienced increased risks, necessitating careful monitoring during medication changes.

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    Area of Science:

    • Clinical Pharmacology
    • Cardiology
    • Pharmacokinetics

    Background:

    • The transition from digitoxin to digoxin around 2012 potentially increased patient health risks.
    • This study aimed to monitor individual patient outcomes during this medication switch.

    Purpose of the Study:

    • To evaluate the impact of switching from digitoxin to digoxin on patient serum concentrations.
    • To assess the associated health risks and therapeutic outcomes during this transition.

    Main Methods:

    • Retrospective review of serum concentrations of digitoxin and digoxin.
    • Analysis of data from St Olavs University Hospital between January 2011 and December 2013.
    • Inclusion of patients with measured serum concentrations before and after the switch.

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    Main Results:

    • 304 patients and 1858 serum concentration analyses were included.
    • Therapeutic serum concentrations were maintained in over 56% of patients post-switch.
    • A reduction in digitalis serum concentration was observed in 58.9% of patients, but toxic concentrations rose from 0.3% to 3.0%.

    Conclusions:

    • The digitoxin to digoxin switch led to reduced serum concentrations for many patients.
    • However, a notable proportion of patients experienced potentially harmful increases in toxic serum concentrations.
    • Close patient monitoring is crucial during such medication substitutions to mitigate health risks.