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Effect of Diterpenes on Hepatic System
Márcia F C J Paz1,2, Muhammad T Islam3,4, Shams Tabrez5
1Northeast Biotechnology Network (RRENORBIO), Post-Graduate Program in Biotechnology, Federal University of Piaui, Teresina (PI)-64.049-550, Brazil.
Current Pharmaceutical Design
|October 3, 2018
Summary
Diterpenes show promising hepatoprotective effects through antioxidant and anti-inflammatory actions, but can also cause liver toxicity. Further research is needed to understand their complex mechanisms on the hepatic system.
Area of Science:
- Pharmacology
- Hepatology
- Natural Products Chemistry
Background:
- Hepatic system complications are a significant health concern.
- Diterpenes, a class of essential oils, possess antioxidant and cytotoxic properties.
- Their potential organo-protective effects make them targets for health promotion.
Purpose of the Study:
- To review and analyze evidence on diterpenes and their effects on the hepatic system.
- To discuss the hepatoprotective and hepatotoxic activities of diterpenes.
Main Methods:
- Literature search of PubMed and Science Direct databases (June 2011 - June 2016).
- Data sorting and activity-wise findings discussion.
- Focus on diterpenes' impact on liver health and function.
Main Results:
- Diterpenes exhibit hepatoprotective properties via multiple pathways including antioxidant, anti-inflammatory, antimicrobial, anticancer, hypolipidemic, anti-apoptosis, autophagic, antimetastasize, anti-proliferating, and anti-fibrosis mechanisms.
- Hepatotoxic effects include cytotoxicity, apoptotic cell death, and downregulation of cytochrome P450 systems.
- Specific diterpenes have demonstrated both beneficial and toxic effects on the liver, particularly in rodent models.
Conclusions:
- Diterpenes present a dual role in hepatic system health, offering protection but also posing risks.
- Extensive research is recommended to elucidate the precise mechanisms of action of diterpenes on the liver.
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