Related Experiment Video
Updated: Feb 4, 2026
04:44
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
20.9K
Gender differences in early systemic sclerosis patients: a report from the EULAR scleroderma trials and research
Patricia E Carreira1, Loreto Carmona2, Beatriz E Joven3
1Servicio de Reumatología, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Spain. carreira@h12o.es.
Clinical and Experimental Rheumatology
|October 3, 2018
Summary
In early systemic sclerosis (SSc), men often exhibit more severe disease signs and symptoms than women. These differences are particularly noted in the limited cutaneous subset, impacting clinical presentation and organ involvement.
Area of Science:
- Rheumatology
- Immunology
- Dermatology
Background:
- Systemic sclerosis (SSc) is a complex autoimmune disease characterized by fibrosis, vascular abnormalities, and immune dysregulation.
- Clinical presentation and disease progression in SSc can vary significantly between sexes.
- Understanding these sex-based differences is crucial for tailored patient management.
Purpose of the Study:
- To delineate the clinical differences between men and women in early systemic sclerosis (<3 years duration).
- To analyze these differences across various SSc disease subsets.
- To identify potential implications for clinical practice and patient management.
Main Methods:
- Cross-sectional analysis of the prospective EULAR Scleroderma Trial and Research (EUSTAR) database.
- Inclusion of patients meeting preliminary ACR 1980 classification criteria for SSc with early disease duration (<3 years).
- Descriptive and bivariate analyses of SSc-related variables, including antibodies, subsets, disease activity, and organ involvement.
Main Results:
- A cohort of 1,027 early SSc patients was analyzed (80% women, 90% Caucasian).
- Men with early SSc more frequently presented with active disease, diffuse cutaneous subset, anti-Scl-70 antibodies, elevated acute phase reactants, and muscular/pulmonary involvement compared to women.
- These sex-based differences were significant in the limited SSc subset but not in the diffuse subset.
Conclusions:
- Men with early systemic sclerosis tend to exhibit more severe disease manifestations.
- In the limited SSc subset, men may present with clinical features overlapping with the diffuse SSc subgroup.
- Recognizing these sex-specific differences can aid in optimizing treatment strategies for individual patients.
More Related Videos
Related Concept Videos
01:24Data Reporting and Recording
5.5K
Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.5K
01:30Socioemotional Experience and Gender Development
332
Social-emotional experiences and cultural influences play significant roles in shaping gender development. During middle childhood, from ages 6 to 11, peer groups become dominant in reinforcing gender norms. Children in this age group often align with same-gender peer groups, which actively encourage behaviors that conform to traditional gender roles. For instance, boys may be discouraged from engaging in activities perceived as feminine, reinforcing culturally dictated norms about masculinity...
332
01:11Clinical Trials: Overview
5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
01:12Trial and Error and Algorithm
424
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
424
01:16Clinical Trials
10.7K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
10.7K
01:16Electric Potential and Potential Difference
5.7K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.7K