Related Experiment Video

Updated: Feb 4, 2026

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress
09:20

The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

Published on: October 31, 2016

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Implications of endothelial shear stress on systemic sclerosis vasculopathy and treatment

Tracy M Frech1, Daniel R Machin2, Maureen A Murtaugh2

  • 1University of Utah, Department of Internal Medicine; University of Utah Hospitals and Clinics; and VAMC Salt Lake City, GRECC, Salt Lake City, UT, USA. tracy.frech@hsc.utah.edu.

Clinical and Experimental Rheumatology
|October 3, 2018
PubMed

Insights

Systemic sclerosis digital ulcers lack FDA-approved treatments. This review explores vasodilatory therapies targeting vascular function and endothelial shear stress for prevention and treatment of these ulcers.

Area of Science:

  • Cardiovascular Medicine
  • Rheumatology
  • Vascular Biology

Background:

  • Systemic sclerosis (SSc) patients often develop digital ulcers (DU) due to prolonged ischemia from Raynaud's phenomenon.
  • Current treatments for SSc-related DU primarily focus on vasodilation through various pathways.
  • There is a lack of FDA-approved drugs specifically for SSc-related DU in the United States.

Purpose of the Study:

  • To review vascular tone and endothelial function in SSc.
  • To provide a rationale for longitudinal studies on vascular function in SSc patients.
  • To support the use of therapeutics targeting endothelial shear stress and vasodilation for DU treatment and prevention.

Main Methods:

  • Literature review of existing studies on vascular function in SSc.
  • Analysis of therapeutic pathways for vasodilation.
  • Discussion of endothelial shear stress as a therapeutic target.

Main Results:

  • Vasodilatory medications aim to relax vascular smooth muscle.
  • Endothelial dysfunction plays a significant role in SSc vascular complications.
  • Targeting endothelial shear stress offers a potential therapeutic avenue.

Conclusions:

  • Vasodilatory medications are crucial for managing SSc-related DU.
  • Longitudinal studies are needed to understand medication effects on vascular function.
  • Access to non-FDA approved vasodilatory medications should be considered for SSc DU treatment.

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