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Effect of Delayed Cord Clamping of Term Babies on Neurodevelopment at 12 Months: A Randomized Controlled Trial

Nisha Rana1,2, Ashish Kc1,3, Mats Målqvist1

  • 1Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Neonatology
|October 3, 2018
PubMed

Insights

Delayed cord clamping (DCC) improves infant neurodevelopment at 12 months. This study found fewer infants undergoing DCC were at risk for developmental delays compared to early cord clamping (ECC).

Area of Science:

  • Neonatal care
  • Developmental pediatrics
  • Public health

Background:

  • Delayed cord clamping (DCC) is linked to better iron status, reduced anemia, and improved long-term development.
  • Previous assessments of DCC's developmental impact have not been conducted in high-iron deficiency prevalence settings.

Purpose of the Study:

  • To investigate the effects of DCC versus early cord clamping (ECC) on infant development.
  • To evaluate neurodevelopment using the Ages and Stages Questionnaire (ASQ) at 12 months of age.

Main Methods:

  • A randomized controlled trial involving 540 full-term deliveries comparing DCC (≥180s) to ECC (≤60s).
  • Infant development was assessed at 12 months using the ASQ, with scores below 1 SD from the mean indicating "at risk" status.

Main Results:

  • Fewer infants in the DCC group were "at risk" for neurodevelopmental issues (7.8% vs. 18.1% in ECC).
  • The DCC group showed significantly higher mean ASQ total scores and improved scores in communication, gross motor, and personal-social domains.

Conclusions:

  • Delayed cord clamping (DCC) after 3 minutes is associated with improved overall neurodevelopment at 12 months.
  • DCC demonstrates a protective effect against neurodevelopmental risks compared to early cord clamping (ECC).
Abstract

Keywords:
Ages and Stages QuestionnaireDelayed umbilical cord clampingImproved neurodevelopment

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