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Published on: June 16, 2014
Association between MPO-463G > A polymorphism and chronic kidney disease: a meta-analysis
Jiaxuan Qin1,2,3, Jinchun Xing1,2,3, Wei Li1,2,3
1a Department of Urology Surgery , The First Affiliated Hospital of Xiamen University , Xiamen , Fujian , China.
Background/Objective:
Previous studies have shown that MPO -463G > A (rs2333227) might be associated with chronic kidney disease (CKD) susceptibility, but sample sizes of those studies are relatively small. Hence, we decided to perform a meta-analysis to evaluate the association. Methods/main results: Two investigators search databases systematically and independently. Odds ratios and 95% confidence intervals were used to pool the effect size. Four articles with 618 cases and 932 controls in total were included in our meta-analysis.
Conclusions:
MPO -463G > A was not associated with CKD susceptibility in recessive model and homozygote comparison. MPO -463G > A was associated with increased risk of CKD in allelic comparison, heterozygote comparison and dominant model, however, the results lacked stability. Owing to insufficient data, the association between MPO -463G > A and CKD cannot be fully confirmed.
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