Related Experiment Video

Updated: Feb 4, 2026

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System
07:09

Hepatic Progenitor Specification from Pluripotent Stem Cells using a Defined Differentiation System

Published on: May 10, 2020

5.4K

Redox cell signaling and hepatic progenitor cells

Giorgia di Bello1, Gianluigi Vendemiale1, Francesco Bellanti1

  • 1Centre for Experimental and Regenerative Medicine, Institute of Internal Medicine, Department of Medical and Surgical Sciences, University of Foggia, Italy.

European Journal of Cell Biology
|October 4, 2018
PubMed

Insights

Reactive species impact stem cell function in liver disease. Understanding redox balance is key for developing stem cell therapies for liver regeneration and treating liver failure.

Area of Science:

  • Hepatology and regenerative medicine.
  • Cellular signaling and redox biology.

Background:

  • Liver diseases necessitate innovative treatments beyond transplantation.
  • Stem cells offer a promising avenue for liver disease therapy.
  • Oxidative stress from reactive species is a hallmark of liver disease.

Purpose of the Study:

  • To review redox-sensitive signaling pathways in stem cell fate.
  • To highlight hepatic progenitor cells for liver regeneration.
  • To explore stem cell-based treatments for end-stage liver disease.

Main Methods:

  • Literature review of redox biology and stem cell research.
  • Analysis of signaling pathways regulating stem cell function.
  • Focus on hepatic progenitor cells in liver disease models.

Main Results:

  • Reactive species play a dual role in cell growth and differentiation.
  • Redox balance is critical for hepatic progenitor cell development and survival.
  • Specific redox-sensitive pathways influence stem cell fate.

Conclusions:

  • Hepatic progenitor cells are a viable source for liver regeneration.
  • Targeting redox pathways could enhance stem cell therapies.
  • Further research into stem cell-based treatments for liver failure is warranted.
Keywords:
Chronic liver diseasesHepatic progenitor cellsOxidative stressRedox cell signalingRegenerative medicine

More Related Videos

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K
Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.7K

Related Concept Videos

What is Cell Signaling?02:03

What is Cell Signaling?

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
130.9K
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.5K
Balancing Redox Equations02:58

Balancing Redox Equations

Electrochemistry is the science involved in the interconversion of electrical and chemical reactions. Such reactions are called reduction-oxidation, or redox reactions. These important reactions are defined by changes in oxidation states for one or more reactant elements and include a subset of reactions involving the transfer of electrons between reactant species. Electrochemistry as a field has evolved to yield sufficient insights on the fundamental principles of redox chemistry and multiple...
62.2K
Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
58.8K
Overview of Cell Signaling01:23

Overview of Cell Signaling

Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
24.8K
Cell Signaling in Plants01:25

Cell Signaling in Plants

Plant cells communicate to coordinate their cycle of growth, flowering and fruiting, and activities in roots, shoots, and leaves in response to the changing environmental conditions. Plant signaling is distinct from animal signaling. Plants primarily utilize enzyme-linked receptors, whereas the largest class of cell-surface receptors in animals are G-protein coupled receptors (GPCRs). Unlike animals, receptor tyrosine kinases are rare in plants. Instead, plants have a diverse class of...
6.2K