Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

840
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
840
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.2K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.2K
Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

567
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
567
Histone Modification02:32

Histone Modification

16.2K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.2K
Muscle Contraction01:15

Muscle Contraction

96.3K
 
96.3K
Muscle Contraction01:10

Muscle Contraction

8.9K
In skeletal muscles, acetylcholine is released by nerve terminals at the motor endplate—the point of synaptic communication between motor neurons and muscle fibers. The binding of acetylcholine to its receptors on the sarcolemma allows entry of sodium ions into the cell and triggers an action potential in the muscle cell. Thus, electrical signals from the brain are transmitted to the muscle. Subsequently, the enzyme acetylcholinesterase breaks down acetylcholine to prevent excessive...
8.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Oxygen defect engineering modifies NiFe<sub>2</sub>O<sub>4</sub> for efficient detection of n-butanol gas.

Mikrochimica acta·2026
Same author

Wave dispersion analysis of porous functionally graded piezoelectric sandwich panels on Kerr substrates.

Scientific reports·2026
Same author

Evaluating the interpretability of clinical speech AI models: Lessons from two user studies.

Computer speech & language·2026
Same author

Factors Associated With Medication Safety Competence Among Clinical Nurses in China: A Latent Profile Analysis.

The journal of nursing research : JNR·2026
Same author

Heterogeneous social isolation and its psychosocial and functional correlates in older adults with chronic heart failure: An integrated latent profile and network analysis.

Geriatric nursing (New York, N.Y.)·2026
Same author

A LINE-1 insertion upstream of FOXP2 promotes neuronal differentiation during primate evolution.

Genome biology·2026
Same journal

Ultrasound-Informed State Estimation of Wrist Tremor Dynamics via Koopman Operator for Personalized Sensory Peripheral Nerve Stimulation.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Motion Intention Recognition and DDPG-Based Adaptive Impedance Control for a Robotic Upper-Limb Exoskeleton.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

CNN-Based Modelling Reveals Temporal Brain Dynamics of Auditory Intensity Processing.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Pathology-Informed Augmentation Improves Cross-Cohort IMU-to-vGRF Estimation Between Healthy Adults and Adults With Osteoarthritis.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Effects of task-driven head orientations on gait and balance during walking in virtual reality.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same journal

Wearable sensor-based Mild Cognitive Impairment Identification: A Multi-Domain Gait Analysis Approach with Association Rule Mining.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
See all related articles

Related Experiment Video

Updated: Feb 4, 2026

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

20.2K

A Fatigue Involved Modification Framework for Force Estimation in Fatiguing Contraction.

Lingfeng Xu, Xiang Chen, Shuai Cao

    IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
    |October 4, 2018
    PubMed
    Summary
    This summary is machine-generated.

    This study introduces a novel framework to improve muscle force estimation by incorporating a fatigue index. The method significantly reduces errors, enhancing applications in biomechanics, rehabilitation, and prosthetics.

    More Related Videos

    Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
    07:22

    Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

    Published on: February 20, 2020

    6.3K
    Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test
    06:00

    Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test

    Published on: July 27, 2015

    13.1K

    Related Experiment Videos

    Last Updated: Feb 4, 2026

    The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
    09:25

    The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

    Published on: May 31, 2016

    20.2K
    Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
    07:22

    Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

    Published on: February 20, 2020

    6.3K
    Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test
    06:00

    Determining The Electromyographic Fatigue Threshold Following a Single Visit Exercise Test

    Published on: July 27, 2015

    13.1K

    Area of Science:

    • Biomechanics
    • Biomedical Engineering
    • Rehabilitation Science

    Background:

    • Muscle fatigue negatively impacts the accuracy of force estimation models.
    • Existing models often fail to account for fatigue-induced changes in muscle behavior.
    • Accurate force estimation is crucial for biomechanical analysis, rehabilitation, and prosthetic control.

    Purpose of the Study:

    • To develop a fatigue-modified force estimation framework to mitigate the effects of muscle fatigue.
    • To establish a relationship between fatigue indices and force estimation model parameters.
    • To enhance the performance and robustness of muscle force estimation models.

    Main Methods:

    • Collected muscle force and surface electromyography (sEMG) data using high-density electrodes and a dynamometer.
    • Applied multi-step signal pre-processing and non-negative matrix factorization (NMF) for signal optimization and fatigue index extraction.
    • Trained a degree 4 polynomial fitting model, correlating its parameters with extracted fatigue indices for real-time modification.

    Main Results:

    • The proposed fatigue-modified force estimation model demonstrated significant improvements across various testing scenarios, including different sexes and ages.
    • Achieved notable reductions in percentage root mean square error (RMSE): 36.5% for young males, 20.7% for young females, and 20.4% for elderly males.
    • The model's performance enhancement was consistent, indicating its effectiveness in real-world applications.

    Conclusions:

    • The developed framework effectively alleviates the negative impacts of muscle fatigue on force estimation accuracy.
    • This approach offers a valuable tool for advancing biomechanical studies, optimizing rehabilitation treatments, and improving prosthetic device functionality.
    • The integration of fatigue indices provides a robust method for dynamic force prediction in diverse populations.