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Customizing a Cryolite Glass Prosthetic Eye

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Systemic inflammation and eye diseases. The Beijing Eye Study.

Jost B Jonas^1,2, Wen Bin Wei³, Liang Xu¹

¹Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing, China.

|October 4, 2018

Summary

Higher serum high-sensitivity C-reactive protein (hs-CRP) levels correlate with increased diabetic retinopathy and polypoidal choroidal vasculopathy in Chinese adults. This suggests a link between systemic inflammation and these specific eye conditions, but not others like glaucoma or AMD.

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Area of Science:

Ophthalmology
Internal Medicine
Public Health

Background:

Systemic inflammation is a potential risk factor for various ocular diseases, including age-related macular degeneration (AMD).
High-sensitivity C-reactive protein (hs-CRP) is a widely used biomarker for systemic inflammation.

Purpose of the Study:

To investigate the association between serum hs-CRP concentrations and the presence and severity of different eye diseases in a Chinese population.
To determine if systemic inflammation, indicated by hs-CRP, is linked to specific ocular conditions.

Main Methods:

A population-based study (Beijing Eye Study) involving 3468 Chinese individuals aged 50 and above.
Participants underwent interviews and comprehensive ophthalmic examinations.
Serum hs-CRP levels were measured and analyzed in relation to various ocular diseases using multivariate analysis.

Main Results:

Higher serum hs-CRP concentrations were significantly associated with a higher level of diabetic retinopathy (P = 0.007) and polypoidal choroidal vasculopathy (P = 0.002).
These associations remained significant after adjusting for factors like high-density lipoproteins, body mass index, education, and cognitive function.
No significant associations were found between serum hs-CRP levels and glaucoma, cataracts, retinal vein occlusions, central serous choroidopathy, or age-related macular degeneration (AMD).

Conclusions:

Elevated serum hs-CRP levels are linked to increased diabetic retinopathy and polypoidal choroidal vasculopathy in Chinese adults aged 50+.
The findings suggest that systemic inflammation plays a role in these specific eye conditions.
Unlike diabetic retinopathy and polypoidal choroidal vasculopathy, other major ocular diseases studied do not appear to be associated with significant systemic inflammation.