[A brief introduction of local allergic rhinitis]

Local allergic rhinitis（local allergic rhinitis, LAR） is a newly proposed concept in recent years. It refers to patients with typical allergic rhinitis symptoms but skin prick test (SPT) and serum specificity IgE are negative, while nasal mucosa can produce local specific IgE and allergen provocation test (NAPT) are positive. The rate of clinical misdiagnose is high. The diagnosis mainly relies on typical nasal symptoms, positive NAPT and/or detection of local specific IgE. It needs to be distinguished from allergic rhinitis(AR) and non-allergic rhinitis (NAR). The main mechanism of its onset is the Th2-type allergic inflammatory response mediated by locally produced IgE. Eosinophils and mast cells are also involved in the inflammatory process. The current study considers LAR to be a separate disease from AR. Allergen immunotherapy(AIT) can be used to treat the disease..