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Published on: August 26, 2017
Peripheral arterial tonometry and angiogenic biomarkers in preeclampsia
Kristina Kumer1, Tanja Premru-Sršen2,3, Vesna Fabjan-Vodušek2
1a Institute of Clinical Chemistry and Biochemistry , University Medical Centre Ljubljana , Ljubljana , Slovenia.
Objective:
To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future.
Methods:
Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay.
Results:
Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy. Women who developed PE had a decreased PlGF and PlGF/(sFlt-1+ sEng) ratio and an increased sEng, and sFlt-1/PlGF ratio.
Conclusion:
Peripheral arterial analysis did provide additional information beyond serum biomarkers in the diagnosis of PE.
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