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Updated: Feb 4, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Exploring a Novel Screening Method for Patients with Oral Squamous Cell Carcinoma: A plasma Metabolomics Analysis
Yui Enomoto1, Akira Kimoto1, Hiroaki Suzuki1
1Department of Oral Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Aim:
This study aimed to explore novel metabolite biomarker candidates for screening oral squamous cell carcinoma (OSCC).
Patients & Methods:
We collected plasma samples from 48 patients with OSCC and 29 with an oral disease and conducted a plasma metabolomics analysis of patients with OSCC using gas chromatography mass spectrometry. Then, we used the cross-validation procedure to ensure the accuracy of biomarker candidates.
Results:
We selected four biomarker candidates against OSCC. Their sensitivity was more than 90%, and the AUC was over 0.9 according to the receiver operating characteristic curve analysis.
Conclusions:
The findings of this study suggest four potential metabolites as biomarkers for OSCC screening.
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