Inhalation of Ketamine in Different Doses to Decrease the Severity of Postoperative Sore Throat in Surgeries under...

Area of Science:

• Anesthesiology and Pain Management
• Pharmacology
• Surgical Patient Care

Background:

• Postoperative sore throat (POST) is a common complication, affecting 21%-65% of patients.
• Nebulization of ketamine has shown promise in mitigating POST.

Purpose of the Study:

• To evaluate the effectiveness of nebulized ketamine at different dosages in reducing POST.
• To assess any potential adverse effects associated with nebulized ketamine administration.

Main Methods:

• A prospective, randomized, double-blind controlled trial involving 150 patients (ASA physical status I and II, aged 18-60).
• Patients were randomized into three groups: nebulized ketamine 25 mg (K1), 50 mg (K2), or normal saline (S).
• POST was assessed using a four-point scale at 2, 4, 8, 12, and 24 hours postoperatively; hemodynamic monitoring was continuous.

Main Results:

• The overall incidence of POST was 29.33%. Group S (saline) showed 46% incidence, while Group K1 (25 mg ketamine) had 20% and Group K2 (50 mg ketamine) had 22% (P ≤ 0.05).
• Both ketamine groups demonstrated significantly lower POST incidence compared to the control group.
• Intraoperative vital signs remained more stable across all time intervals in the ketamine groups.

Conclusions:

• Nebulized ketamine, at both 25 mg and 50 mg doses, is highly effective in preventing postoperative sore throat.
• The two tested doses of nebulized ketamine exhibited comparable efficacy in reducing POST.
• No adverse effects were reported with the use of nebulized ketamine for POST prevention.