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Analysis and Imaging of Osteocytes
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Parathyroid Hormone Signaling in Osteocytes
1Endocrine Unit, Massachusetts General Hospital Harvard Medical School Boston MA USA.
JBMR Plus
|October 5, 2018
Summary
Parathyroid hormone (PTH) directly influences osteocyte function, regulating key genes like SOST and RANKL. This review explores novel mechanisms of PTH and PTH-related peptide (PTHrP) in modulating bone homeostasis via osteocytes.
Area of Science:
- Bone Biology
- Cellular Mechanisms
- Skeletal Remodeling
Background:
- Osteocytes are the most abundant bone cells, orchestrating skeletal remodeling.
- Osteocytes are critical cellular targets of parathyroid hormone (PTH).
Purpose of the Study:
- To review cellular and molecular mechanisms of PTH action on osteocyte function.
- To highlight novel mechanisms of PTH and PTHrP in modulating bone homeostasis through osteocytes.
Main Methods:
- Review of existing literature on PTH signaling in osteocytes.
- Discussion of molecular mechanisms regulating SOST and RANKL gene expression.
Main Results:
- PTH regulates osteocyte expression of SOST and RANKL.
- PTH/PTHrP signaling influences osteocyte remodeling of the perilacunar environment.
- Novel mechanisms of PTH/PTHrP action on bone homeostasis via osteocytes are presented.
Conclusions:
- Osteocytes are key mediators of PTH action in bone.
- PTH and PTHrP signaling in osteocytes offers novel therapeutic targets for bone diseases.
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