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One-Pot Total Synthesis of Evodiamine and Its Analogues through a Continuous Biscyclization Reaction
Zi-Xuan Wang1, Jia-Chen Xiang1, Miao Wang1
1Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry , Central China Normal University , Wuhan 430079 , P. R. China.
Abstract:
The one-pot total synthesis of evodiamine and its analogues is achieved using a three-component reaction. Through continuous biscyclization, various readily available substrates with good functional group tolerance were easily incorporated into biologically active quinazolinocarboline backbones. The use of triethoxymethane as a cosolvent was crucial for this quick and straightforward transformation.
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