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Updated: Feb 4, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors
Yanchun Liu1, Yijie Wang1, Jason Chakroff2
11 The Research Institute at Nationwide Children's Hospital, Columbus, Ohio.
Impact Statement:
This study compared side-by-side the impact of donor age on the production of tissue-engineered small intestine (TESI). Each age represents a specific period of life: E18 for fetuses, 5-day-old pups for neonates, 21-day-old rats for weanlings, and 6-week-old rats for adults. The TESI produced was compared macroscopically and microscopically. The mechanism(s) contributing to the differences observed was explored by detecting proliferating cells in the TESI and by analyzing intestinal stem cell gene expression in donor cells. These data may provide valuable information for future application of TESI clinically.
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