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Updated: Feb 10, 2026

Quadruple Immunostaining of the Olfactory Bulb for Visualization of Olfactory Sensory Axon Molecular Identity Codes
Published on: June 5, 2017
Local GABAergic modulation of noradrenaline release in the rat olfactory bulb measured on superfused slices
Abstract:
Ascending noradrenergic projections from locus coeruleus reaching the rat olfactory bulb (OB) synapse onto gamma-aminobutyric acid (GABA)-ergic interneurons. We tested the hypothesis that these interneurons could locally modulate noradrenaline (NA) release. On superfused OB slices, GABA (10, 100 and 1000 microM) enhanced potassium-evoked release of newly accumulated [3H]NA. This raises the possibility that GABAergic interneurons could establish a functional link between olfactory deutoneuron activity and NA release in the rat OB.
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