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Acupuncture for irritable bowel syndrome: study protocol for a multicenter randomized controlled trial.

Li-Xia Pei1, Hao Geng1, Hao Chen2

  • 1Department of Acupuncture, Jiangsu Province Hospital of Traditional Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No 155, Hanzhong Road, Qinhuai District, Nanjing, 210029, China.

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|October 5, 2018
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Summary

This study investigates acupuncture for Irritable Bowel Syndrome (IBS), a chronic gastrointestinal disorder. It aims to determine acupuncture

Keywords:
AcupunctureAcupuncture effectIrritable bowel syndromeProtocolRandomized controlled trials

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Area of Science:

  • Gastroenterology
  • Integrative Medicine
  • Genetics

Background:

  • Irritable Bowel Syndrome (IBS) is a prevalent chronic gastrointestinal disorder impacting quality of life and presenting complex pathophysiology.
  • Acupuncture is recognized as a potential alternative therapy for managing IBS symptoms.
  • Existing research lacks comprehensive understanding of IBS genetic subtypes and their response to acupuncture.

Purpose of the Study:

  • To evaluate the efficacy and safety of acupuncture as a treatment for Irritable Bowel Syndrome (IBS).
  • To explore the relationship between specific IBS-gene subtypes and the effectiveness of acupuncture therapy.
  • To provide a rigorous, evidence-based assessment of acupuncture for IBS management.

Main Methods:

  • A multicenter randomized controlled trial involving 600 participants stratified by IBS subtype (IBS-C or IBS-D).
  • Comparison of acupuncture treatment against Western medicine over a 6-week intervention period with a 3-month follow-up.
  • Assessment of outcomes using the IBS-Symptom Severity Score (IBS-SSS) and IBS-Quality of Life (IBS-QoL) scores, with genetic analysis via PCR-RFLP.

Main Results:

  • Primary outcome: Change in IBS-Symptom Severity Score (IBS-SSS) from baseline to 6 weeks.
  • Secondary outcome: Change in IBS-Quality of Life (IBS-QoL) score.
  • Exploration of genetic correlations with treatment response.

Conclusions:

  • This study is a significant multicenter randomized controlled trial conducted in China assessing acupuncture for IBS.
  • Findings are anticipated to clarify the therapeutic efficacy of acupuncture as an alternative option for IBS patients.
  • This research pioneers the investigation into the genomic mechanisms underlying IBS and their interaction with acupuncture treatment.