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Encapsulation of Cardiomyocytes in a Fibrin Hydrogel for Cardiac Tissue Engineering

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Published on: September 19, 2011

Engineering hydrogel viscoelasticity.

Ludovica Cacopardo¹, Nicole Guazzelli², Roberta Nossa¹

¹Research Centre "E. Piaggio", University of Pisa, Largo Lucio Lazzarino 1, 56122 Pisa, Italy; Department of Information Engineering, University of Pisa, Via Girolamo Caruso 16, 56122 Pisa, Italy.

Journal of the Mechanical Behavior of Biomedical Materials

|October 5, 2018

Summary

This summary is machine-generated.

Researchers modified hydrogel viscoelastic properties by altering fluid viscosity, not elasticity. This method, using dextran solutions, offers a new tool for mechanobiology research on cell responses to substrate stiffness.

Keywords:

Agarose Damping component modulation Mechanobiology Polyacrylamide Viscoelasticity

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Published on: May 25, 2012

Area of Science:

Biomaterials Science
Polymer Chemistry
Mechanobiology

Background:

Hydrogels are crucial in biomedical applications, but controlling their viscoelastic properties independently of elastic moduli is challenging.
Understanding cell responses to substrate viscoelasticity requires tunable material properties.

Purpose of the Study:

To develop a method for modifying the time-dependent viscoelastic properties of hydrogels without altering their elastic component.
To investigate the effect of aqueous phase viscosity on hydrogel viscoelasticity.

Main Methods:

Agarose and acrylamide hydrogels were prepared in aqueous dextran solutions of varying concentrations (0-5% w/v) to alter viscosity.
Viscoelastic properties were measured using the epsilon-dot method (compression tests at varying strain rates).
Data were analyzed using a standard linear solid model.

Main Results:

Increasing liquid viscosity in control sponges increased relaxation time (τ) while elastic moduli remained constant.
In hydrogels, increasing liquid viscosity significantly reduced instantaneous modulus (Einst) and relaxation time (τ).
Equilibrium elastic modulus (Eeq) remained independent of liquid viscosity in both hydrogels and controls.

Conclusions:

Hydrogel viscoelastic behavior can be modulated by altering the aqueous phase viscosity, offering a strategy to decouple elastic and viscous properties.
This approach allows for the study of cell responses to substrate viscoelasticity while maintaining a constant elastic cue (Eeq).
The findings have implications for mechanobiology research and biomaterial design.