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Updated: Feb 4, 2026
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
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RIFM fragrance ingredient safety assessment, ethyl 2-methyl-1,3-dioxolane-2-acetate, CAS Registry Number 6413-10-1
Summary
Ethyl 2-methyl-1,3-dioxolane-2-acetate demonstrates no genotoxicity or skin sensitization concerns. Safety assessments confirm no adverse effects for repeated dose, reproductive, or local respiratory toxicity, with environmental safety also established.
Area of Science:
- Chemical safety assessment
- Toxicology
- Environmental risk evaluation
Background:
- Ethyl 2-methyl-1,3-dioxolane-2-acetate (CAS # 6413-10-1) is a chemical compound requiring comprehensive safety evaluation.
- Understanding its toxicological profile and environmental impact is crucial for regulatory compliance and safe use.
Purpose of the Study:
- To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of Ethyl 2-methyl-1,3-dioxolane-2-acetate.
- To determine safety margins and potential risks associated with its use.
Main Methods:
- Genotoxicity assays were performed.
- Repeated dose, developmental, and reproductive toxicity were assessed to calculate Margin of Exposure (MOE).
- Local respiratory toxicity was evaluated against the Threshold of Toxicological Concern (TTC). Phototoxicity/photoallergenicity was assessed via UV spectra. Environmental safety was determined using IFRA Environmental Standards and risk quotients (PEC/PNEC).
Main Results:
- Ethyl 2-methyl-1,3-dioxolane-2-acetate was found to be non-genotoxic.
- No safety concerns were identified for skin sensitization at current use levels.
- MOE values >100 were calculated for repeated dose, developmental, and reproductive toxicity.
- Exposure levels for local respiratory toxicity were below the TTC.
- The compound is not expected to be phototoxic or photoallergenic.
- Ethyl 2-methyl-1,3-dioxolane-2-acetate is not considered Persistent, Bioaccumulative, and Toxic (PBT).
- Risk quotients for the aquatic environment were <1, indicating no significant risk.
Conclusions:
- Ethyl 2-methyl-1,3-dioxolane-2-acetate presents a favorable safety profile across multiple toxicological endpoints.
- The compound is considered safe for use under specified conditions, with no significant environmental risks identified.
- Comprehensive safety data supports the continued use of Ethyl 2-methyl-1,3-dioxolane-2-acetate.
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