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Lymphomatoid granulomatosis mimicking cancer and sarcoidosis
Grosse Alexandra1, Grosse Claudia2
1Institute of Pathology and Molecular Pathology, University Hospital Zurich, Rämistrasse 100, 8091, Zürich, Switzerland. Alexandra.Grosse@usb.ch.
Abstract:
Two cases of misdiagnoses of lymphomatoid granulomatosis are discussed here. Lymphomatoid granulomatosis is an Epstein-Barr virus-associated lymphoproliferative disorder with aggressive behavior. Due to its rarity and many presentations, delay in diagnosis and treatment is common. Its histological features including large atypical B-cells, T cell predominance, angiocentricity, necrosis, and evidence of EBV-positive cells should elicit the diagnosis of lymphomatoid granulomatosis. The settings that are described here have not yet been described in the literature.
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