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Updated: Feb 4, 2026

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
Published on: November 10, 2011
Correction: Liver enzymes
Brian Agganis1, David Lee2, Thomas Sepe3
1Department of Internal Medicine, Brown University, Providence, RI, USA. brian.agganis@lifespan.org.
Abstract:
In the article by Agganis B, Lee D, Sepe T (Liver enzymes: No trivial elevations, even if asymptomatic. Cleve Clin J Med 2018; 85(8):612-617, doi:10.3949/ccjm.85a.17103), an error occurred on page 613, in the second paragraph in the section about alcohol intake. The words ALT and AST were reversed. The paragraph should read as follows: The exact pathogenesis of alcoholic hepatitis is incompletely understood, but alcohol is primarily metabolized by the liver, and damage likely occurs during metabolism of the ingested alcohol. AST elevations tend to be higher than ALT elevations; the reason is ascribed to hepatic deficiency of pyridoxal 5'-phosphate, a cofactor of the enzymatic activity of ALT, which leads to a lesser increase in ALT than in AST. We thank Avinash Alexander, MD, Texas Tech University Health Sciences Center, for calling this to our attention. The correction has been made online.
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