[Electrocardiographic aspects of morphogenesis of neuroleptic cardiopathy]

Neuroleptic cardiomyopathy (NCMP) is a consequence of cardiotoxic side effect of antipsychotic drugs. Changes of ECG associated with this condition are poorly known.

To elucidate dynamics of ECG at different clinical stages of NCMP and evaluate its diagnostic value. Methods. We determined the frequency and informative values of 8 different ECG signs includingQTinterval corrected based at theBazettformula (QTc). Their informative value was estimated from the Kullback formula. The data obtained were analyzed by parametric and non-parametric statistics methods.

Pathological changes of ECG parameters associated with NCM Preflect processes of structural rearrangement in the heart at different levels of its organization. The analysis of the available information showed that almost all ECG parameters have high diagnostic value listed in the following rank order (frequency/informativeness): rhythm disorder - 1/8, prolongation of the QTc interval - 4/3, conduction disorder - 2/2, diffuse muscular changes - 3/1, right heart overload - 5/6, left ventricular hypertrophy - 7-8/5, impaired electrical activity of myocardium - 7-8/5, deviation of the electrical axis to the left - 6/4. It seems appropriate to distinguish the following three maximally informative (and therefore most important) ECG signs indicative of developing NCMP: diffuse muscular changes, conduction disorder, and prolongation of the QTc interval.

The analysis of the available information provides a new insight into dynamics of ECG signs associated with NCMP and permits to estimate the diagnostic value of pathological changes for its earlier detection.