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Updated: Feb 4, 2026
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
Published on: April 10, 2018
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Long non-coding RNA HOXD-AS1 in cancer
Lianlian Li1, Yong Wang2, Xiaoyu Zhang1
1Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan 250062, China.
Summary
Long non-coding RNA HOXD-AS1 plays a key role in various cancers. Aberrant HOXD-AS1 expression correlates with clinical features and impacts tumor progression, suggesting its potential as a cancer biomarker and therapeutic target.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Long non-coding RNAs (lncRNAs) are implicated in tumorigenesis and cancer progression.
- The HOXD-AS1 gene, located in the HOXD cluster, is increasingly recognized for its role in various cancers.
Purpose of the Study:
- To review the biological functions and mechanisms of HOXD-AS1 in human cancers.
- To explore HOXD-AS1's potential as a diagnostic/prognostic biomarker and therapeutic target.
Main Methods:
- Literature review of studies on HOXD-AS1 in human cancers.
- Analysis of HOXD-AS1 expression patterns and their correlation with clinical features.
- Investigation of HOXD-AS1's regulatory mechanisms in tumor cell growth, invasion, and migration.
Main Results:
- HOXD-AS1 is aberrantly expressed in multiple cancers, including bladder, cervical, colorectal, gastric, ovarian, prostate, glioma, hepatocellular carcinoma, melanoma, osteosarcoma, and non-small cell lung cancer.
- Aberrant HOXD-AS1 expression is associated with patient clinical features.
- HOXD-AS1 influences tumor cell growth, invasion, and migration through diverse molecular mechanisms.
Conclusions:
- HOXD-AS1 is a significant factor in the development and progression of various human cancers.
- HOXD-AS1 holds promise as a potential diagnostic/prognostic biomarker for cancer.
- HOXD-AS1 represents a potential novel therapeutic target for cancer treatment.
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