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Physiological effects of Type 2 diabetes on mRNA processing and gene expression

Faer S Morrison1, Karen A Johnstone1, Lorna W Harries1,2

  • 1a Institute of Biomedical and Clinical Science, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, EX2 5DW, UK.

Expert Review of Endocrinology & Metabolism
|October 7, 2018
PubMed
Summary

High blood glucose and raised lipids in type 2 diabetes alter gene expression through various mechanisms. This gene dysregulation may worsen diabetic conditions and complications.

Keywords:
alternative splicingdiabetesepigeneticgene expressionglucolipotoxicityhyperglycemiahyperlipidemiamiRNAoxidative stress

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