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Chuzhen Therapy as a Non-Invasive Traditional Chinese Therapy for Neck Pain

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Postradiation therapy hypopituitarism.

Betül A Hatipoglu¹, Laurence Kennedy^1,2

¹a Department of Endocrinology, Cleveland Clinic, Cleveland, OH 44124, USA.

Expert Review of Endocrinology & Metabolism

|October 7, 2018

Summary

Radiation therapy for head and neck tumors can cause pituitary insufficiency. The somatotropic and gonadotropic axes are most vulnerable, while posterior pituitary function is rarely affected.

Keywords:

corticotropin gonadotropins growth hormone hypopituitarism precocious puberty radiation radiosurgery thyrotropin

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Area of Science:

Endocrinology
Radiation Oncology
Oncology

Background:

Radiation therapy for head and neck cancers and other tumors, including pituitary adenomas, has increased since the mid-20th century.
This has led to recognition of potential pituitary function impairment, often resulting in pituitary insufficiency.
Current knowledge primarily stems from observational and retrospective studies, with limited randomized prospective data.

Purpose of the Study:

To review the impact of radiation treatment on pituitary function.
To identify particularly vulnerable pituitary axes and potential effects of newer techniques like stereotactic radiosurgery.

Main Methods:

Review of existing observational and retrospective studies on radiation therapy effects on pituitary function.
Analysis of data regarding specific pituitary axes (somatotropic, gonadotropic, posterior pituitary) and their vulnerability.
Consideration of the impact of stereotactic radiosurgery versus conventional radiation therapy.

Main Results:

Radiation treatment can impair pituitary function, leading to insufficiency.
The somatotropic and gonadotropic axes are particularly vulnerable and may be affected early.
Posterior pituitary function is rarely impacted by radiation therapy.
Stereotactic radiosurgery may reduce the impact on normal pituitary function, but long-term data is limited.

Conclusions:

Radiation therapy poses a risk of pituitary insufficiency, particularly affecting the somatotropic and gonadotropic axes.
Further prospective studies are needed to fully evaluate the long-term effects of stereotactic radiosurgery on pituitary function.