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Related Experiment Videos

Mapping the human brain's cortical-subcortical functional network organization.

Jie Lisa Ji1, Marjolein Spronk2, Kaustubh Kulkarni2

  • 1Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

Neuroimage
|October 7, 2018
PubMed
Summary

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Network neuroscience (Cambridge, Mass.)·2026

Researchers mapped the human brain's large-scale functional networks, integrating cortical and subcortical regions into a comprehensive whole-brain atlas. This new resource aids studies on brain function and disorders.

Area of Science:

  • Neuroscience
  • Systems Neuroscience
  • Computational Neuroscience

Background:

  • Understanding complex systems like the human brain necessitates characterizing architecture across multiple organizational levels.
  • Large-scale brain network organization provides a crucial framework for integrating lower-level structures.

Purpose of the Study:

  • To characterize the human brain's large-scale network organization by integrating cortical and subcortical structures.
  • To develop and validate a principled approach for identifying functional network communities.
  • To create a comprehensive whole-brain functional network atlas.

Main Methods:

  • Developed a principled community detection algorithm calibrated with known sensory and motor systems.
  • Identified and expanded upon existing cortical networks, including higher-order cognitive networks.
Keywords:
Brain connectivityBrain networksFunctional MRIResting-state functional connectivity

Related Experiment Videos

  • Extended cortical network mapping to subcortical regions, identifying 358 organized subcortical parcels.

    • Main Results:

    • Replicated and expanded known cortical networks, identifying novel higher-order networks like a language network.
    • Revealed 358 highly organized subcortical parcels integrated into whole-brain functional networks.
    • The number of identified subcortical parcels (~358) closely matched recent estimates for cortical parcels (~360).

    Conclusions:

    • A novel whole-brain network atlas integrating cortex and subcortex has been created.
    • This atlas provides a unified functional framework for all brain structures.
    • The atlas is released as an open resource to facilitate future research on large-scale brain networks in health and disease.