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Related Experiment Video

Updated: Feb 4, 2026

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

Published on: May 5, 2011

Lighting Up Cancer Dynamics.

Pavithran T Ravindran¹, Maxwell Z Wilson²

¹Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, USA.

Trends in Cancer

|October 8, 2018

Summary

This summary is machine-generated.

Cellular optogenetics reveals how mutations alter the Ras-to-Erk pathway

Keywords:

MAP kinase cancer cellular optogenetics signaling dynamics

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Area of Science:

Cellular dynamics and disease mechanisms
Molecular signaling in cancer biology

Background:

Live-cell microscopy shows complex, time-varying signaling pathway activities.
The link between signaling dynamics and cellular disease is not well understood.

Purpose of the Study:

To investigate the Ras-to-Erk signaling pathway's transfer function in cancer cells using optogenetics.
To understand how altered pathway dynamics contribute to disease.

Main Methods:

Utilized cellular optogenetics for precise control and analysis of signaling pathways.
Focused on the Ras-to-Erk pathway's response to extracellular signals in cancer cells.

Main Results:

Demonstrated that changes in pathway filtering properties can lead to misinterpretation of extracellular events.
Revealed that mutations can subtly alter pathway transmission properties, not just cause hyperactivation.

Conclusions:

Mutations in signaling pathways can alter their dynamic transmission properties, impacting cellular function.
Understanding these altered dynamics is crucial for comprehending cancer development and progression.