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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Abnormal Functional Connectivity Density in Post-Stroke Aphasia.

Jing Guo1,2, Mi Yang3, Bharat B Biswal1,4

  • 1MOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.

Brain Topography
|October 8, 2018
PubMed
Summary
This summary is machine-generated.

Post-stroke aphasia (PSA) involves altered brain connectivity. This study found specific changes in short- and long-range functional connectivity density, linking some changes to speech impairment in patients.

Keywords:
Functional connectivity densityPost-stroke aphasiaResting-state functional magnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Post-stroke aphasia (PSA) is a language disorder often resulting from left hemisphere damage.
  • Previous research suggests PSA is linked to functional integration abnormalities in the brain.

Purpose of the Study:

  • To investigate functional connectivity density (FCD) in individuals with PSA using resting-state functional magnetic resonance imaging (rs-fMRI).
  • To compare short- and long-range FCD between PSA patients and healthy controls (HC).
  • To correlate FCD values in affected regions with speech scores in PSA patients.

Main Methods:

  • Resting-state functional magnetic resonance imaging (rs-fMRI) was employed.
  • Functional connectivity density (FCD) was analyzed for both short- and long-range connections.
  • Pearson's correlation analysis was used to assess the relationship between FCD and speech scores.

Main Results:

  • Individuals with PSA exhibited increased short-range FCD in contralesional areas (temporal gyrus, inferior frontal gyrus, thalamus, insula, mesial temporal gyrus) and increased long-range FCD in the contralesional mesial temporal gyrus.
  • Decreased short-range FCD was observed in ipsilesional frontal gyrus, caudate, thalamus, fusiform gyrus, and mesial temporal gyrus.
  • Decreased long-range FCD was found in ipsilesional superior temporal gyrus, fusiform gyrus, and mesial temporal gyrus.
  • Reduced long-range FCD in the left superior temporal gyrus positively correlated with spontaneous speech scores.

Conclusions:

  • Altered FCD patterns in PSA reflect disrupted functional connectivity post-stroke, contributing to language and cognitive deficits.
  • Findings provide novel voxel-level insights into intra- and inter-regional interactions in PSA pathophysiology.
  • This research advances understanding of the neural basis of language impairment after stroke.