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Updated: Feb 4, 2026

One-anastomosis Gastric Bypass OAGB in Rats
Published on: November 10, 2018
Anti-inflammatory effects of gastric bypass surgery and their association with improvement in metabolic profile
Karl J Neff1, Patrick K O'Donohoe1, Carel W le Roux1,2
1a 1 Diabetic Complication Research Centre, UCD Conway Institute, University College Dublin, Dublin, Ireland.
Abstract:
Obesity is associated with chronic inflammation and metabolic disease. Bariatric surgery offers a treatment that can effectively reduce weight and improve the metabolic function. However, the effect of bariatric surgery on chronic inflammation in obesity is under-investigated. In this expert review, the authors outline the effect of Roux-en-Y gastric bypass, the most commonly performed bariatric surgery in current practice, on the markers of inflammation. They include a discussion of the relationship between inflammation and weight loss after surgery, the interaction between these markers and metabolic disease, and the effect on adipose tissue inflammation. They also briefly explore the role of glucagon-like-peptide 1 in remediating inflammation and the changes in gut microbiota after Roux-en-Y gastric bypass, and how they may be important in inflammation.
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