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Endocrinology of bone/brain crosstalk
Alessia Metozzi1, Lorenzo Bonamassa1, Gemma Brandi2
1a 1 Department of Surgery and Translational Medicine, Metabolic Bone Diseases Unit, University of Florence, Largo Palagi 1, 50138 Florence, Italy.
Expert Review of Endocrinology & Metabolism
|October 9, 2018
Summary
Discover the fascinating link between the nervous system and bone health. Neuro-skeletal research reveals how neuronal regulation influences bone metabolism, impacting osteoblasts and osteoclasts.
Area of Science:
- Neuroscience
- Skeletal Biology
- Endocrinology
Background:
- Bone metabolism is primarily regulated by osteoblasts and osteoclasts.
- Genetic, hormonal, and lifestyle factors influence bone health.
- Emerging research highlights a 'bone-brain crosstalk' system, indicating a direct relationship between bone and the nervous system.
Purpose of the Study:
- To explore the neuronal regulation of bone metabolism.
- To introduce the concept of 'bone-brain crosstalk' and its implications.
- To establish the foundation for the new field of neuroskeletal research.
Main Methods:
- Historical review of anatomical and physiological studies on bone innervation.
- Synthesis of current observations on neuronal and neuropeptide regulation of bone remodeling.
- Identification of key research areas within neuroskeletal science.
Main Results:
- The nervous system directly influences bone tissue.
- Neurons and neuropeptides originating in the CNS play a role in regulating bone remodeling.
- A historical understanding of bone innervation has evolved into a dedicated research field.
Conclusions:
- The neuroskeletal system represents a significant area of scientific inquiry.
- Understanding bone-brain crosstalk is crucial for comprehending bone metabolism.
- Further research in neuroskeletal science promises new insights into bone health and disease.
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