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Updated: Feb 4, 2026

Multiple Intravenous Bolus Dosing and Invasive Hemodynamic Assessment in a Hypoxia-Induced Mouse Pulmonary Artery Hypertension Model
Published on: November 11, 2022
[Arterial hypertension with multiple organ damage: A new entity?]
Sophie Kuntz1, Romain Boulestreau2, Sébastien Rubin3
1CHU de Bordeaux, hôpital Saint-André, 1, rue Jean-Burguet, 33000 Bordeaux, France.
Hypertensive emergencies, a condition with stable or increasing incidence, require prompt diagnosis and management. Early intervention improves outcomes, even without visible eye damage, to prevent multi-organ damage.
Area of Science:
- Cardiology
- Nephrology
- Ophthalmology
Background:
- Hypertensive emergency incidence remains stable or is increasing, often underdiagnosed.
- Early and specific management significantly improves patient prognosis.
- Diagnosis should not be delayed by the absence of eye damage or fundus examination access.
Purpose of the Study:
- To define and highlight the importance of managing hypertensive emergencies.
- To introduce a new definition for Multi-Organ Damage Hypertension.
- To emphasize timely diagnosis and intervention regardless of ocular findings.
Main Methods:
- Review of existing literature and clinical guidelines on hypertensive emergencies.
- Analysis of diagnostic criteria and management strategies.
- Definition of Multi-Organ Damage Hypertension based on blood pressure and target organ involvement.
Main Results:
- Hypertensive emergencies have a stable or increasing incidence, with many cases being underdiagnosed.
- Effective management is crucial for improving prognosis.
- Multi-Organ Damage Hypertension is defined by a sudden, persistent blood pressure rise without a specific threshold, affecting at least three target organs (brain, heart, kidney, endothelium) or causing ocular involvement.
Conclusions:
- Prompt diagnosis and management of hypertensive emergencies are critical for better outcomes.
- The absence of ocular findings should not impede the diagnosis of hypertensive emergency.
- Multi-Organ Damage Hypertension represents a severe hypertensive state requiring immediate attention and intervention.
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Hypertension I: Introduction

