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Spatial and temporal coordination of antiviral responses by group 1 ILCs
Nicholas M Adams1,2, Joseph C Sun1,2,3
1Immunology Program, Memorial Sloan Kettering Cancer Center, New York.
Abstract:
Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC1 responses that collectively serve to achieve optimal viral control.
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