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Related Concept Videos

Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Nucleic acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
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Amino acids03:42

Amino acids

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Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
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Polyprotic Acids03:38

Polyprotic Acids

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Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
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Related Experiment Video

Updated: Feb 4, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Phenylboronic Acid-polymers for Biomedical Applications.

Ji Hyun Ryu1,2, Gyeong Jin Lee3, Yu-Ru V Shih1

  • 1Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, North Carolina, NC 27703, United States.

Current Medicinal Chemistry
|October 9, 2018
PubMed
Summary
This summary is machine-generated.

Phenylboronic acid-polymers (PBA-polymers) offer versatile biomedical applications due to their unique diol interactions. This review highlights their stimuli-responsive, self-healing, and shear-thinning properties derived from dynamic boronate ester bonds.

Keywords:
Phenylboronic acidhydrogelspolymersreversibleself-healingstimuli-responsive.

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Materials Science

Background:

  • Phenylboronic acid-polymers (PBA-polymers) are stimuli-responsive materials with significant potential in biomedical fields.
  • Their unique characteristic lies in reversible covalent bond formation with diols, crucial for applications like drug delivery and tissue engineering.

Purpose of the Study:

  • To review the chemistry, synthesis, and diverse biomedical applications of PBA-polymers.
  • To emphasize the role of dynamic boronate ester bonds in PBA-polymer functionalities.

Main Methods:

  • Comprehensive literature search across Scopus, PubMed, and Google Scholar.
  • Focus on phenylboronic acid chemistry, PBA-polymer synthesis, and their biomedical uses.

Main Results:

  • Summarized findings from approximately 179 peer-reviewed articles.
  • Highlighted PBA-polymers' interaction with diols, forming dynamic boronate esters.
  • Discussed pH sensitivity, self-healing, and shear-thinning properties of PBA-based materials.

Conclusions:

  • Incorporating phenylboronic acid into polymer chains imparts diverse functionalities without altering intrinsic properties.
  • PBA-polymers exhibit unique characteristics driven by the dynamic nature of boronate ester groups, enabling advanced biomedical applications.