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Updated: Feb 4, 2026
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
[Metabolomic Profiling of Patients With Cardiovascular Diseases]
Y N Belenkov1, E V Privalova1, M V Kozhevnikova1
1I.M. Sechenov First Moscow State Medical University (Sechenov University).
Insights
Metabolomics, a powerful diagnostic tool, shows promise in identifying early biomarkers for cardiovascular diseases (CVD). This approach analyzes metabolic profiles to detect endothelial dysfunction (ED), a key factor in CVD development.
Area of Science:
- Biochemistry
- Clinical Diagnostics
- Biomarker Discovery
Background:
- Cardiovascular diseases (CVD) are the leading global cause of mortality.
- Endothelial dysfunction (ED) plays a critical role in the pathogenesis and progression of CVD.
- Identifying early markers for ED is crucial for timely intervention and improved patient outcomes.
Purpose of the Study:
- To explore the application of metabolomics in identifying early biomarkers for CVD.
- To highlight the potential of metabolomic profiling in understanding CVD pathogenesis.
- To discuss the role of metabolomics in detecting endothelial dysfunction.
Main Methods:
- Utilizing metabolomic analysis, primarily based on mass spectrometry.
- Studying comprehensive metabolic profiles and their alterations.
- Correlating metabolic deviations with genetic, proteomic, and environmental factors.
Main Results:
- Metabolomics enables the study of complete metabolic profiles and their deviations.
- This approach has demonstrated significant success in various scientific and clinical applications.
- Metabolomic analysis is emerging as a promising method for early CVD biomarker detection.
Conclusions:
- Metabolomics offers a powerful approach for the early diagnosis of diseases, including CVD.
- It provides insights into the pathogenetic mechanisms of CVD by assessing endothelial dysfunction.
- Further research in metabolomic profiling holds significant potential for advancing cardiovascular medicine.
Abstract:
Cardiovascular diseases (CVD) are the main cause of death worldwide. A broad study of the pathogenetic mechanisms of the CVD onset and progression has led to understanding of the importance of endothelial dysfunction (ED) in these processes. During recent years intensive work has been conducted in the direction of searching for markers of ED. Metabolomics is an intensively advancing approach to early diagnostics of diseases. Metabolomic analysis based on mass spectrometry allows to study complete metabolic profiles and their deviations resulting from changes in expression of genes and RNA, protein activity, or environmental factors. Metabolomic analysis has already demonstrated significant results in the solving of different scientific and clinical problems. It appears to be a promising method for detecting early biomarkers of CVD. Various aspects of application of metabolomic profiling in the field of cardiovascular diseases are discussed in this article.
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