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Carbohydrates are an essential part of the diet in humans and animals. Grains, fruits, and vegetables are natural sources of carbohydrates that provide energy to the body, particularly through glucose, a simple sugar that is a component of starch and an ingredient in many staple foods. The stoichiometric formula (CH2O)n, where n is the number of carbons in the molecule represents carbohydrates. In other words, the ratio of carbon to hydrogen to oxygen is 1:2:1 in carbohydrate molecules. This...
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Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to...
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Light-driven Enzymatic Decarboxylation
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Chemistry-driven glycoscience.

Laura L Kiessling1

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Bioorganic & Medicinal Chemistry
|October 10, 2018
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Summary
This summary is machine-generated.

Cell surface carbohydrates act as identification cards, mediating vital biological processes. This study explores carbohydrate recognition mechanisms, developing probes to understand their physiological roles in host-microbe interactions and immunity.

Area of Science:

  • Carbohydrate chemistry and structural biology
  • Glycobiology and cell surface interactions

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  • Molecular recognition mechanisms
  • Background:

    • Cell surface carbohydrates (glycans) function as critical identifiers, mediating cell-cell communication and host-microbe interactions.
    • Glycan recognition by proteins is fundamental to physiological processes like fertilization, development, and immune responses.
    • Understanding these interactions is key to deciphering biological functions and developing therapeutic strategies.