[Pemetrexed-induced eyelid edema]

Area of Science:

• Oncology
• Dermatology
• Ophthalmology

Background:

• Drug-induced eyelid edema is an uncommon adverse event.
• Chemotherapy agents, particularly pemetrexed, can precipitate this condition.

Observation:

• A 56-year-old male patient developed progressive, non-itchy eyelid edema after pemetrexed-carboplatin chemotherapy for lung adenocarcinoma with brain metastases.
• No other causes for the edema were identified.

Findings:

• The patient was diagnosed with pemetrexed-induced eyelid edema.
• This adverse event is exceedingly rare, with only 22 reported cases in medical literature.
• The exact mechanism of pemetrexed-induced eyelid edema is unknown, but capillary protein leakage is a hypothesized cause.

Implications:

• Accurate diagnosis requires ruling out other potential causes of eyelid edema.
• Management of chemotherapy-induced eyelid edema can be challenging.
• Surgical intervention has shown promise in resolving this condition without recurrence.