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Ceramide Synthase 6: Comparative Analysis, Phylogeny and Evolution.

Roger S Holmes1,2, Keri A Barron3, Natalia I Krupenko4

  • 1Griffith Research Institute for Drug Discovery and School of Environment and Science, Griffith University, Nathan, QLD 4111, Australia. r.holmes@griffith.edu.au.

Biomolecules
|October 10, 2018
PubMed
Summary
This summary is machine-generated.

Ceramide synthase 6 (CerS6) is a distinct enzyme crucial for producing C14 and C16 ceramides in the endoplasmic reticulum. Its conserved role throughout vertebrate evolution highlights its fundamental importance.

Keywords:
CerS6ceramide synthaseenzymesgeneshumaninvertebratesmousevertebratesyeast

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Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • Ceramide synthase 6 (CerS6), also known as LASS6, is one of six human ceramide synthase genes.
  • Ceramides are vital lipids involved in various cellular functions.
  • Understanding CerS6's specific role and evolutionary conservation is crucial.

Purpose of the Study:

  • To investigate the evolutionary conservation and functional role of CerS6.
  • To analyze CerS6 gene structure, protein sequence, and regulatory elements.

Main Methods:

  • Comparative genomics across vertebrate species.
  • Sequence alignment and structural prediction of CerS6 protein.
  • Analysis of gene structure, promoter region, and 3'-UTR.

Main Results:

  • CerS6 is identified as the specific endoplasmic reticulum C14- and C16-ceramide synthase.
  • High sequence similarity (90-100%) among mammalian CerS6 proteins, distinct from other CerS family members.
  • Identification of key conserved residues, including the active site.
  • Human CERS6 gene features a CpG island, multiple transcription factor binding sites, and 15 miRNA target sites.
  • Phylogenetic analysis confirms strong conservation of CerS6 throughout vertebrate evolution.

Conclusions:

  • CerS6 plays a distinct and conserved role in ceramide synthesis across vertebrates.
  • The gene's regulatory elements suggest precise transcriptional control and signaling functions.
  • CerS6 is a unique and evolutionarily significant member of the ceramide synthase family.