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Hemophilia A Complicated by Ulcerative Colitis.
Maxim Olivier1, Mario Madruga1, S J Carlan2
1Department of Medicine, Orlando Regional Healthcare, Orlando, Florida, USA.
Case Reports in Gastrointestinal Medicine
|October 10, 2018
Summary
Patients with Hemophilia A and ulcerative colitis (UC) face severe bleeding risks. Prompt, concurrent treatment of both conditions is crucial for managing this rare but dangerous complication.
Area of Science:
- Hematology
- Gastroenterology
Background:
- Hemophilia A is a genetic bleeding disorder due to Factor VIII deficiency.
- Ulcerative colitis (UC) is an inflammatory bowel disease (IBD).
- UC is reportedly less common in patients with bleeding disorders.
Observation:
- A 26-year-old male with Hemophilia A presented with prolonged rectal bleeding.
- Bleeding persisted despite Factor VIII replacement therapy.
- Colonoscopy and biopsy confirmed active UC.
Findings:
- Concurrent Hemophilia A and UC can lead to severe, prolonged hemorrhage.
- Underlying Factor VIII deficiency exacerbates bleeding in UC patients.
Implications:
- Concurrent management of Hemophilia A and UC is essential.
- Multidisciplinary tertiary care is recommended for optimal patient outcomes.
- Early recognition and treatment are vital to prevent potentially fatal bleeding.
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