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Biomarkers for acute cardiorenal syndrome

Pei-Chun Fan1,2, Chih-Hsiang Chang1,2, Yung-Chang Chen3

  • 1Department of Nephrology, Kidney Research Center, Chang Gung Memorial Hospital, Linkou Medical Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Nephrology (Carlton, Vic.)
|October 10, 2018
PubMed

Insights

Emerging biomarkers offer improved early detection and assessment for cardiorenal syndrome type I (CRS I), a condition involving heart and kidney dysfunction. These markers aid in differential diagnosis, severity evaluation, and prognosis, enhancing patient management for CRS I.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarker Research

Background:

  • Cardiorenal syndromes involve heart and kidney dysfunction.
  • Cardiorenal syndrome type I (CRS I) is acute kidney injury from acute cardiac dysfunction.
  • Traditional markers like serum creatinine have limitations in diagnosing CRS I.

Purpose of the Study:

  • Review emerging biomarkers for CRS I.
  • Evaluate their potential for early detection and diagnosis.
  • Assess their role in disease severity and prognosis.

Main Methods:

  • Literature review of emerging biomarkers.
  • Analysis of biomarker utility in CRS I.
  • Comparison with traditional diagnostic markers.

Main Results:

  • Several biomarkers show promise for CRS I.
  • These include BNP, sST2, angiopoietin, and others.
  • Biomarkers may improve early detection and prognosis.

Conclusions:

  • Emerging biomarkers can enhance CRS I diagnosis and management.
  • They offer advantages over traditional markers for CRS I.
  • Improved patient outcomes are anticipated with biomarker use.

Keywords:
biomarker, cardiorenal syndrome, acute kidney injury

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