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Updated: Feb 4, 2026

In vivo and in vitro Studies of Adaptor-clathrin Interaction
Published on: January 26, 2011
Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88
Masatoshi Uno1, Takahiro Watanabe-Nakayama, Hiroki Konno
1Department of Biophysics, Kyoto University, Kyoto, 606-8502, Japan. tochio@mb.biophys.kyoto-u.ac.jp.
Abstract:
MyD88 (myeloid differentiation factor 88) is an important protein in innate immunity. Two structural domains of MyD88 have been well characterized separately, but the global architecture of full-length MyD88 remained unclear. Here, we propose an autosuppressive mechanism of MyD88 regulated by the intramolecular interaction between the two domains.
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