Related Experiment Video

Updated: Feb 4, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

[Modern approaches to the problem of hypertrophic cardiomyopathy]

V Yu Kaplunova, G A Shakar'yants, M V Kozhevnikova

    Klinicheskaia Meditsina
    |October 10, 2018
    PubMed

    Insights

    This review details hypertrophic cardiomyopathy (HCM), a hereditary heart muscle disease. It covers epidemiology, hemodynamics, clinical symptoms, and disease variants to guide patient management strategies.

    Area of Science:

    • Cardiology
    • Genetics
    • Internal Medicine

    Background:

    • Hypertrophic cardiomyopathy (HCM) is a primary hereditary disease affecting the myocardium.
    • Understanding its epidemiology and pathophysiology is crucial for effective clinical management.

    Purpose of the Study:

    • To present current data on hypertrophic cardiomyopathy (HCM).
    • To analyze epidemiological features, pathophysiological changes, and clinical manifestations of HCM.
    • To explore different clinical course variants and inform management strategies.

    Main Methods:

    • Literature review of modern scientific data on hypertrophic cardiomyopathy.
    • Analysis of epidemiological, pathophysiological, and clinical aspects.
    • Examination of disease variants and their clinical presentations.

    Main Results:

    • Detailed overview of hypertrophic cardiomyopathy (HCM) epidemiology and pathophysiology.
    • Description of the formation of key clinical symptoms and disease variants.
    • Insights into the clinical picture of different HCM variants.

    Conclusions:

    • Modern concepts of hypertrophic cardiomyopathy (HCM) aid in understanding disease variants.
    • Understanding clinical manifestations of each variant is key for patient management.
    • This review provides a basis for selecting optimal management strategies for HCM patients.

    More Related Videos

    A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring05:54

    A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring

    Published on: November 29, 2024

    2.2K
    Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model06:22

    Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model

    Published on: November 29, 2024

    1.5K

    Related Concept Videos

    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    490
    Cardiomyopathy II: Dilated Cardiomyopathy01:30

    Cardiomyopathy II: Dilated Cardiomyopathy

    Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
    568
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
    538
    Modern Molecular Taxonomy01:29

    Modern Molecular Taxonomy

    Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
    686
    Cardiomyopathy V: Interprofessional Care01:29

    Cardiomyopathy V: Interprofessional Care

    Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
    442
    Cardiomyopathy I: Introduction and Classification01:25

    Cardiomyopathy I: Introduction and Classification

    Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
    605