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Related Experiment Videos

Why are Behçet's disease patients always exhausted?

Amal A Senusi1, Jie Liu1, Dorian Bevec2

  • 1Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK.

Clinical and Experimental Rheumatology
|October 10, 2018
PubMed
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Behçet

Area of Science:

  • Immunology
  • Neuroendocrinology
  • Artificial Intelligence in Medicine

Background:

  • Behçet's disease (BD) is characterized by significant fatigue and sleep disturbances impacting daily life.
  • The underlying mechanisms linking BD to these symptoms are not fully understood.
  • Artificial intelligence (AI) was employed to identify potential biomarkers associated with fatigue and sleep issues in BD.

Purpose of the Study:

  • To investigate the association between fatigue, sleep quality, and disease activity in BD patients.
  • To assess the circulating concentrations of alpha-melanocyte stimulating hormone (α-MSH), vasoactive intestinal peptide (VIP), and inflammatory cytokines.
  • To explore the role of these biomarkers in the manifestation of fatigue and sleep disorders in BD.

Main Methods:

Related Experiment Videos

  • A cohort of 127 participants, including 97 BD patients and 30 healthy controls (HC), was studied.
  • Participants completed the Multi-Dimensional Assessment of Fatigue (MAF) and Pittsburgh Sleep Quality Index (PSQI) questionnaires.
  • Serum concentrations of α-MSH, VIP, IL-1β, IL-6, IL-10, and TNF-α were measured using enzyme-linked immunosorbent assays (ELISA).

    • Main Results:

    • 64% of BD patients reported high fatigue, and 63% experienced poor sleep quality.
    • BD patients exhibited significantly higher MAF and PSQI scores, along with elevated serum levels of α-MSH, VIP, and IL-6 compared to HC.
    • α-MSH and IL-6 significantly correlated with fatigue and sleep quality, while VIP influenced sleep quality and disease activity.

    Conclusions:

    • Circulating α-MSH, VIP, and IL-6 are implicated in the pathophysiology of fatigue and sleep disturbances in Behçet's disease.
    • Understanding these complex interactions may pave the way for novel therapeutic strategies.
    • Targeting these biomarkers could potentially improve management of fatigue, sleep disorders, and disease activity in BD.