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Updated: Feb 4, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
Published on: January 24, 2025
A New Strategy for Intestinal Drug Delivery via pH-Responsive and Membrane-Active Nanogels
Shiqi Wang1, Youlim Ha1, Xiaozhen Huang1
1Department of Chemical Engineering , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.
Abstract:
Oral administration of hydrophobic and poorly intestinal epithelium-permeable drugs is a significant challenge. Herein, we report a new strategy to overcome this problem by using novel, pH-responsive, and membrane-active nanogels as drug carriers. Prepared by simple physical cross-linking of amphiphilic pseudopeptidic polymers with pH-controlled membrane-activity, the size and hydrophobicity-hydrophilicity balance of the nanogels could be well-tuned. Furthermore, the amphiphilic nanogels could release hydrophobic payloads and destabilize cell membranes at duodenum and jejunum pH 5.0-6.0, which suggests their great potential for intestinal drug delivery.
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