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Updated: Feb 4, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
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Genetic Ancestry May Influence the Evolutionary Trajectory of Cancers
Jason J Pitt1, Yonglan Zheng2, Olufunmilayo I Olopade2
1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Abstract:
In this issue of Cancer Cell, Yuan et al. compared the somatic alterations harbored by tumors from European and African ancestry individuals. They determined that the latter group has a propensity for aberrations that are consistent with genomic instability, potentially lending insight to the genomic basis of cancer health disparities.
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