Intratumoral Heterogeneity: Tools to Understand and Exploit Clone Wars in AML
George Giotopoulos1, Brian J P Huntly1
1Wellcome Trust-MRC Cambridge Stem Cell Institute, Cambridge, UK; Department of Haematology, University of Cambridge, Cambridge, UK; Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK.
Cancer Cell
|October 10, 2018
Summary
Researchers identified specific cell surface markers to track acute myeloid leukemia (AML) subclones in patients. This allows for detailed monitoring of cancer evolution and treatment response.
Area of Science:
- Hematology
- Oncology
- Cancer Biology
Background:
- Acute myeloid leukemia (AML) is a heterogeneous cancer with diverse subclones.
- Understanding subclone dynamics is crucial for effective AML treatment and prognosis.
Purpose of the Study:
- To refine and validate a set of plasma membrane markers specific to AML.
- To enable prospective identification, isolation, and longitudinal tracking of leukemic subclones in AML patients.
Main Methods:
- Utilized advanced immunophenotypic profiling.
- Correlated marker expression with mutational signatures and transcriptional data.
- Integrated functional behavior and therapeutic outcome analysis.
Main Results:
- Successfully refined a panel of AML-enriched plasma membrane markers.
- Demonstrated the utility of these markers for identifying and tracking leukemic subclones.
- Established correlations between immunophenotypic profiles, mutations, and clinical outcomes.
Conclusions:
- The refined marker set provides a powerful tool for dissecting AML heterogeneity.
- Longitudinal tracking of subclones can inform personalized therapeutic strategies.
- This approach enhances our understanding of AML evolution and treatment response.
More Related Videos
Related Concept Videos
01:27Reproductive Cloning
32.7K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.7K
01:28Understanding the Self
295
The self is a central aspect of human identity, encompassing an individual’s beliefs, emotions, perceptions, and experiences. It is a cognitive and psychological construct that enables individuals to interpret their traits and behaviors, influencing how they perceive themselves and interact with the world. While personality consists of stable and enduring characteristics, the self is shaped by self-perception and social experiences. This distinction highlights the dynamic nature of the...
295
01:20Understanding Self-Concept
280
The self-concept encompasses individuals' beliefs about themselves, structured through cognitive frameworks known as self-schemas. These schemas function as mental representations of specific traits or behaviors, influencing how self-relevant information is perceived, processed, and remembered. For example, individuals who are schematic for body weight are more likely to interpret routine experiences—such as dining out or shopping—through the lens of that trait. Conversely, those...
280
01:14Understanding Deception
168
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
168
01:27Understanding Love
189
Love, as a multifaceted psychological construct, encompasses emotions, cognitive processes, and behavioral patterns that play a crucial role in human relationships. It extends beyond attraction, manifesting in deep, enduring connections that influence personal well-being and social structures.Psychological Dimensions of LoveLove differs from friendship and mere liking through its depth and intensity. While friendship is built on mutual respect, trust, and companionship, love involves emotional...
189
01:23Understanding Consciousness
2.1K
Consciousness can be defined as the state of being aware of and able to think about one's existence, sensations, and surroundings. It encompasses two major components: awareness and arousal. Awareness pertains to the recognition of environmental stimuli and internal states. At the same time, arousal refers to the physiological readiness to engage with these stimuli, which varies significantly between states like sleep and wakefulness.
Sleep, a crucial state, is characterized by reduced...
Sleep, a crucial state, is characterized by reduced...
2.1K