RIFM fragrance ingredient safety assessment, 1,1-diethoxyheptane, CAS Registry Number 688-82-4.

Area of Science:

• Chemical safety assessment
• Toxicology
• Environmental risk evaluation

Background:

• 1,1-Diethoxyheptane is a chemical compound requiring safety evaluation for its use.
• Existing data and read-across methods are utilized to assess potential hazards.

Purpose of the Study:

• To evaluate the genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety of 1,1-Diethoxyheptane.
• To determine if 1,1-Diethoxyheptane presents any safety concerns under current use conditions.

Main Methods:

• Genotoxicity assessed via read-across from octanal dimethyl acetal.
• Skin sensitization evaluated using the non-reactive DST.
• Repeated dose, developmental, reproductive, and local respiratory toxicity assessed using the Threshold of Toxicological Concern (TTC) for Cramer Class I materials.
• Phototoxicity/photoallergenicity determined by UV spectra analysis.
• Environmental safety assessed for Persistence, Bioaccumulation, and Toxicity (PBT) and by calculating risk quotients (PEC/PNEC).

Main Results:

• 1,1-Diethoxyheptane is not expected to be genotoxic.
• No concern for skin sensitization was identified.
• Toxicity endpoints were evaluated using established TTC values.
• Environmental risk quotients (PEC/PNEC) are <1, indicating no environmental concern.
• 1,1-Diethoxyheptane is not considered a PBT substance according to IFRA Environmental Standards.

Conclusions:

• 1,1-Diethoxyheptane is considered safe for use under current conditions based on the comprehensive safety evaluation.
• The chemical does not pose significant risks for genotoxicity, skin sensitization, or environmental impact.
• Further use of 1,1-Diethoxyheptane is supported by the available safety data.