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Related Experiment Videos

Granular cell tumors.

J G Morrison, G F Gray, A H Dao

    The American Surgeon
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Granular cell tumors (GCTs) are rare lesions typically found in the skin or soft tissue. This study reviewed 31 GCTs in 26 patients, highlighting their varied locations and multifocal potential.

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    Area of Science:

    • Oncology
    • Pathology
    • Dermatology

    Background:

    • Granular cell tumors (GCTs) are uncommon neoplasms of uncertain origin and histogenesis.
    • While typically arising in the skin or soft tissues, GCTs can occur in diverse anatomical sites and may present as multifocal lesions.

    Purpose of the Study:

    • To analyze the clinical presentation, anatomical distribution, and management of granular cell tumors.
    • To describe the experience with 31 GCTs in 26 patients treated at institutional centers.

    Main Methods:

    • Retrospective review of patient records and tumor characteristics.
    • Analysis of tumor location, patient demographics, and treatment modalities.

    Main Results:

    • Thirty-one GCTs were identified in 26 patients (21 female, 12 Black, average age 41.8 years).

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  • The most frequent sites were skin (12 tumors), breast (4), vulva (3), axilla (2), gum (2), buccal cavity (2), and esophagus (2).
  • Two patients had synchronous multifocal lesions, and one patient developed metachronous lesions over 5 years.

    • Conclusions:

    • Granular cell tumors exhibit a predilection for females and Black individuals.
    • These tumors can present as multifocal or metachronous lesions, requiring careful evaluation of anatomical distribution.
    • Surgical excision is the primary treatment modality, with variations based on tumor size and location.