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Updated: Feb 4, 2026

Laparoscopic Duodenum-Preserving Pancreatic Head Resection via Inferior Infracolic Approach: A Surgical Approach for Benign Lesions
Published on: February 9, 2024
Pancreatic extragastrointestinal stromal tumor invading the duodenum
Sinan Yol1, Erdal Polat1, Mustafa Duman1
1Department of Gastrointestinal Surgery, Kartal Koşuyolu Yüksek İhtisas Training and Research Hospital, İstanbul, Turkey.
Extremely rare extragastrointestinal stromal tumors (EGISTs) in the pancreas are challenging to manage. This report details the largest EGIST case found in the pancreatic head, contributing valuable data on these unusual tumors.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Extragastrointestinal stromal tumors (EGISTs) are rare mesenchymal neoplasms originating outside the gastrointestinal tract.
- Pancreatic EGISTs are exceptionally uncommon, posing diagnostic and therapeutic challenges, especially when located in the pancreatic head.
Purpose of the Study:
- To report a rare case of a large extragastrointestinal stromal tumor in the head of the pancreas.
- To contribute to the limited literature on EGISTs in unusual locations, specifically the pancreas.
Main Methods:
- A 56-year-old male patient presented with abdominal pain.
- Diagnostic imaging, including CT and MRI, identified a 10 cm mass in the pancreatic head.
- Surgical resection via pancreaticoduodenectomy was performed.
Main Results:
- A 10 cm extragastrointestinal stromal tumor was successfully excised from the pancreatic head.
- The patient recovered well and was discharged on postoperative day 14.
- This represents the seventh reported case of a pancreatic EGIST in the head and is the largest among them.
Conclusions:
- Pancreatic extragastrointestinal stromal tumors, though rare, require surgical intervention.
- This case highlights the possibility of large EGISTs in the pancreatic head and adds to the collective understanding of these rare tumors.
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